| Player | Team | Rank | IP | W | S | K | ERA | WHIP | |
| Alex Wilson | Det - RP | 228 | 70.0 | 3 | 2 | 38 | 2.19 | 1.03 | |
| Jeff Manship | Cle - RP | 236 | 39.1 | 1 | 0 | 33 | 0.92 | 0.76 | |
| Justin Wilson | Det - RP | 250 | 61.0 | 5 | 0 | 66 | 3.10 | 1.13 | |
| Xavier Cedeño | TB - RP | 278 | 46.0 | 4 | 1 | 47 | 2.35 | 1.17 | |
| Mychal Givens | Bal - RP | 294 | 30.0 | 2 | 0 | 38 | 1.80 | 0.87 | |
| Fernando Salas | LAA - RP | 328 | 63.2 | 5 | 0 | 74 | 4.24 | 1.15 | |
| Matt Albers | CWS - RP | 305 | 37.1 | 2 | 0 | 28 | 1.21 | 1.07 | |
| Zach Duke | CWS - RP | 375 | 60.2 | 3 | 1 | 66 | 3.41 | 1.30 | |
| Fernando Rodríguez | Oak - RP | 335 | 58.2 | 4 | 0 | 65 | 3.84 | 1.14 | |
| Casey Fien | Min - RP | 344 | 63.1 | 4 | 0 | 41 | 3.55 | 1.09 | |
| Chasen Shreve | NYY - RP | 327 | 58.1 | 6 | 0 | 64 | 3.09 | 1.41 | |
| Steve Geltz | TB - RP | 334 | 67.1 | 2 | 2 | 61 | 3.74 | 1.05 | |
| Charlie Furbush | Sea - RP | 365 | 21.2 | 1 | 0 | 17 | 2.08 | 0.65 | |
| Blaine Hardy | Det - RP | 352 | 61.1 | 5 | 0 | 55 | 3.08 | 1.35 | |
| Zach Putnam | CWS - RP | 432 | 48.2 | 3 | 0 | 64 | 4.07 | 1.36 | |
| José Álvarez | LAA - RP | 350 | 67.0 | 4 | 0 | 59 | 3.49 | 1.21 | |
| Brian Matusz | Bal - RP | 376 | 49.0 | 1 | 0 | 56 | 2.94 | 1.18 | |
| Tommy Hunter | Cle - RP | 422 | 60.1 | 4 | 1 | 47 | 4.18 | 1.24 | |
| Evan Scribner | Sea - RP | 382 | 60.0 | 2 | 0 | 64 | 4.35 | 1.03 | |
| Zach McAllister | Cle - RP | 313 | 69.0 | 4 | 1 | 84 | 3.00 | 1.35 | |
| Danny Duffy | KC - SP,RP | 499 | 136.2 | 7 | 1 | 102 | 4.08 | 1.39 | |
| Nate Jones | CWS - RP | 393 | 19.0 | 2 | 0 | 27 | 3.32 | 0.95 | |
| Ryan Tepera | Tor - RP | 412 | 33.0 | 0 | 1 | 22 | 3.27 | 0.88 | |
| Joel Peralta | Sea - RP | 428 | 29.0 | 3 | 3 | 24 | 4.34 | 1.24 | |
| Ryan Webb | TB - RP | 427 | 50.2 | 1 | 0 | 31 | 3.20 | 1.14 | |
| Drew VerHagen | Det - RP | 418 | 26.1 | 2 | 0 | 13 | 2.05 | 1.22 | |
| Junichi Tazawa | Bos - RP | 477 | 58.2 | 2 | 3 | 56 | 4.14 | 1.33 | |
| Jake Petricka | CWS - RP | 461 | 52.0 | 4 | 2 | 33 | 3.63 | 1.42 | |
| Ryan Pressly | Min - RP | 443 | 27.2 | 3 | 0 | 22 | 2.93 | 1.41 | |
| Steven Wright | Bos - SP,RP | 429 | 72.2 | 5 | 0 | 52 | 4.09 | 1.29 | |
| Aaron Loup | Tor - RP | 503 | 42.1 | 2 | 0 | 46 | 4.46 | 1.28 | |
| Dale Thayer | Bal - RP | 597 | 37.2 | 2 | 0 | 25 | 4.06 | 1.38 | |
| Ross Ohlendorf | KC - RP | 457 | 19.1 | 3 | 1 | 19 | 3.72 | 1.45 | |
| Neal Cotts | Hou - RP | 437 | 63.1 | 1 | 0 | 58 | 3.41 | 1.26 | |
| Vance Worley | Bal - SP,RP | 591 | 71.2 | 4 | 0 | 49 | 4.02 | 1.42 | |
| Álex Cláudio | Tex - RP | 480 | 15.2 | 1 | 0 | 13 | 2.87 | 1.15 | |
| Mike Morin | LAA - RP | 543 | 35.1 | 4 | 1 | 41 | 6.37 | 1.27 | |
| Ryan Dull | Oak - RP | 489 | 17.0 | 1 | 1 | 16 | 4.24 | 1.06 | |
| Bo Schultz | Tor - RP | 452 | 43.0 | 0 | 1 | 31 | 3.56 | 1.07 | |
| Gavin Floyd | Tor - RP | 548 | 13.1 | 0 | 0 | 7 | 2.70 | 1.13 | |
| Luke Hochevar | KC - RP | 475 | 50.2 | 1 | 1 | 49 | 3.73 | 1.28 | |
| Shawn Armstrong | Cle - RP | 502 | 8.0 | 0 | 0 | 11 | 2.25 | 0.88 | |
| Cory Rasmus | LAA - RP | 640 | 20.2 | 0 | 0 | 27 | 5.23 | 1.26 | |
| Pat Venditte | Tor - RP | 497 | 28.2 | 2 | 0 | 23 | 4.40 | 1.19 | |
| Randy Choate | Tor - RP | 516 | 27.1 | 1 | 1 | 22 | 3.95 | 1.24 | |
| Tommy Layne | Bos - RP | 553 | 47.2 | 2 | 1 | 45 | 3.97 | 1.43 | |
| Peter Moylan | KC - RP | 520 | 10.1 | 1 | 0 | 8 | 3.48 | 1.16 | |
| Matt Andriese | TB - SP,RP | 492 | 65.2 | 3 | 2 | 49 | 4.11 | 1.32 | |
| Kyle Crockett | Cle - RP | 643 | 17.2 | 0 | 0 | 15 | 4.08 | 1.36 | |
| Jake Diekman | Tex - RP | 534 | 58.1 | 2 | 0 | 69 | 4.01 | 1.44 | |
| Andrew Faulkner | Tex - RP | 547 | 9.2 | 0 | 0 | 10 | 2.79 | 1.14 | |
| James Pazos | NYY - RP | 550 | 5.0 | 0 | 0 | 3 | 0.00 | 1.20 | |
| Heath Hembree | Bos - RP | 512 | 25.1 | 2 | 0 | 15 | 3.55 | 1.34 | |
| Sam Freeman | Tex - RP | 578 | 38.1 | 0 | 0 | 40 | 3.05 | 1.46 | |
| Chaz Roe | Bal - RP | 500 | 41.1 | 4 | 0 | 38 | 4.14 | 1.48 | |
| Al Alburquerque | LAA - RP | 642 | 62.0 | 4 | 0 | 58 | 4.21 | 1.55 | |
| Giovanni Soto | Cle - RP | 568 | 3.1 | 0 | 0 | 0 | 0.00 | 0.90 | |
| Joe Beimel | Sea - RP | 631 | 47.1 | 2 | 1 | 22 | 3.99 | 1.37 | |
| Brian Duensing | KC - RP | 544 | 48.2 | 4 | 1 | 24 | 4.25 | 1.38 | |
| Nick Rumbelow | NYY - RP | 559 | 15.2 | 1 | 0 | 15 | 4.02 | 1.34 | |
| Diego Moreno | NYY - RP | 582 | 10.1 | 1 | 0 | 8 | 5.23 | 1.16 | |
| Melvin Mercedes | Det - RP | - | - | - | - | - | - | - | |
| Luke Jackson | Tex - RP | 605 | 6.1 | 0 | 0 | 6 | 4.26 | 1.11 | |
| Jake Buchanan | Hou - RP | 528 | 9.0 | 0 | 0 | 5 | 2.00 | 1.00 | |
| Wilking Rodríguez | NYY - RP | - | - | - | - | - | - | - | |
| Edwin Escobar | Bos - RP | - | - | - | - | - | - | - | |
| Kevin Chapman | Hou - RP | 595 | 5.1 | 0 | 0 | 8 | 3.38 | 1.31 | |
| Greg Mahle | LAA - RP | - | - | - | - | - | - | - | |
| Nick Burdi | Min - RP | - | - | - | - | - | - | - | |
| Brian Morán | Sea - RP | - | - | - | - | - | - | - | |
| Frank De Los Santos | CWS - RP | - | - | - | - | - | - | - | |
| Jon Keller | Bal - RP | - | - | - | - | - | - | - | |
| Jake Reed | Min - RP | - | - | - | - | - | - | - | |
| Eric Beaulac | Bal - RP | - | - | - | - | - | - | - | |
| Zach Phillips | CWS - RP | - | - | - | - | - | - | - | |
| J.T. Chargois | Min - RP | - | - | - | - | - | - | - | |
| Tony Barnette | Tex - RP | - | - | - | - | - | - | - | |
| Matt Purke | CWS - RP | - | - | - | - | - | - | - | |
| Chris Dwyer | Bal - RP | - | - | - | - | - | - | - | |
| Onelki García | CWS - RP | - | - | - | - | - | - | - | |
| Dan Jennings | CWS - RP | 608 | 56.1 | 2 | 0 | 46 | 3.99 | 1.40 | |
| Matt Tracy | NYY - RP | 622 | 2.0 | 0 | 0 | 1 | 0.00 | 2.00 | |
| Vidal Nuño | Sea - SP,RP | 454 | 89.0 | 1 | 0 | 81 | 3.74 | 1.26 | |
| Jarrett Grube | Cle - RP | - | - | - | - | - | - | - | |
| Chad Jenkins | Tor - RP | 648 | 3.2 | 0 | 0 | 2 | 4.91 | 1.64 | |
| Oliver Drake | Bal - RP | 624 | 15.2 | 0 | 0 | 17 | 2.87 | 1.60 | |
| Bradin Hagens | TB - RP | - | - | - | - | - | - | - | |
| Ben Rowen | Tor - RP | - | - | - | - | - | - | - | |
| José De Paula | NYY - RP | 637 | 3.1 | 0 | 0 | 2 | 2.70 | 1.80 | |
| Jacob Lindgren | NYY - RP | 636 | 7.0 | 0 | 0 | 8 | 5.14 | 1.29 | |
| Branden Pinder | NYY - RP | 623 | 27.2 | 0 | 0 | 25 | 2.93 | 1.52 | |
| Tim Collins | KC - RP | - | - | - | - | - | - | - | |
| Michael Tonkin | Min - RP | 585 | 23.1 | 0 | 0 | 19 | 3.47 | 1.29 | |
| Scott Alexánder | KC - RP | 639 | 6.0 | 0 | 0 | 3 | 4.50 | 1.33 | |
| Justin Marks | TB - RP | - | - | - | - | - | - | - | |
| Austin Adams | Cle - RP | 592 | 33.1 | 2 | 1 | 23 | 3.78 | 1.50 | |
| Steve Delabar | Tor - RP | 629 | 29.1 | 2 | 1 | 30 | 5.22 | 1.43 | |
| Nick Goody | NYY - RP | 669 | 5.2 | 0 | 0 | 3 | 4.76 | 1.59 | |
| Taylor Thompson | Oak - RP | - | - | - | - | - | - | - | |
| Noé Ramírez | Bos - RP | 665 | 13.0 | 0 | 0 | 13 | 4.15 | 1.54 | |
| Scott Snodgress | LAA - RP | - | - | - | - | - | - | - | |
| José Valdez | Det - RP | 677 | 9.0 | 0 | 0 | 4 | 4.00 | 1.56 | |
| Jason García | Bal - RP | 655 | 29.2 | 1 | 0 | 22 | 4.25 | 1.42 | |
| Bryan Price | Cle - RP | - | - | - | - | - | - | - | |
| Ángel Castro | Oak - RP | 687 | 4.0 | 0 | 0 | 4 | 2.25 | 2.75 | |
| Patrick McCoy | Tor - RP | - | - | - | - | - | - | - | |
| Yohan Pino | KC - RP | 610 | 19.1 | 0 | 0 | 13 | 3.26 | 1.34 | |
| Vinnie Pestano | NYY - RP | 720 | 11.2 | 1 | 0 | 13 | 5.40 | 1.97 | |
| Román Méndez | Bos - RP | 740 | 13.2 | 0 | 0 | 10 | 5.27 | 1.61 | |
| Miguel Almonte | KC - RP | 716 | 8.2 | 0 | 0 | 10 | 6.23 | 1.62 | |
| Angel Nesbitt | Det - RP | 714 | 21.2 | 1 | 0 | 14 | 5.40 | 1.38 | |
| Logan Darnell | Min - RP | - | - | - | - | - | - | - | |
| A.J. Achter | LAA - RP | 728 | 13.1 | 0 | 0 | 14 | 6.75 | 1.35 | |
| Deolis Guerra | LAA - RP | 724 | 16.2 | 2 | 0 | 17 | 6.48 | 1.74 | |
| Jeff Ferrell | Det - RP | 735 | 11.1 | 0 | 0 | 6 | 6.35 | 1.41 | |
| Arnold León | Tor - RP | 736 | 26.2 | 0 | 0 | 19 | 4.39 | 1.46 | |
| John Cornely | Bos - RP | 750 | 1.0 | 0 | 0 | 1 | 36.00 | 4.00 | |
| Michael Feliz | Hou - RP | 748 | 8.0 | 0 | 0 | 7 | 7.88 | 1.63 | |
| Bruce Rondon | Det - RP | 729 | 31.0 | 1 | 5 | 36 | 5.81 | 1.61 | |
| Marc Rzepczynski | Oak - RP | 752 | 35.0 | 2 | 0 | 41 | 5.66 | 1.54 | |
| Alex Meyer | Min - RP | 771 | 2.2 | 0 | 0 | 3 | 16.88 | 2.63 | |
| Kyle Ryan | Det - SP,RP | 778 | 56.1 | 2 | 0 | 30 | 4.47 | 1.42 | |
| Ryan O'Rourke | Min - RP | 773 | 22.0 | 0 | 0 | 24 | 6.14 | 1.41 | |
| Brandon Workman | Bos - SP,RP | - | - | - | - | - | - | - | |
| Tyler Olson | NYY - RP | 788 | 13.1 | 1 | 0 | 8 | 5.40 | 2.10 | |
| Jonathan Aro | Sea - RP | 791 | 10.1 | 0 | 0 | 8 | 6.97 | 1.84 | |
| Daniel Coulombe | Oak - RP | 785 | 16.0 | 0 | 0 | 11 | 5.63 | 1.63 | |
| Robbie Ross Jr. | Bos - RP | 484 | 60.2 | 0 | 6 | 53 | 3.86 | 1.30 | |
| Sergio Santos | NYY - RP | 683 | 16.1 | 0 | 0 | 18 | 4.96 | 1.41 | |
| Jeff Francis | Tor - RP | 800 | 22.0 | 1 | 0 | 21 | 6.14 | 1.64 | |
| Phil Klein | Tex - RP | 846 | 17.1 | 1 | 0 | 12 | 6.75 | 1.90 | |
| Kirby Yates | NYY - RP | 829 | 20.1 | 1 | 0 | 21 | 7.97 | 1.48 | |
| Chad Smith | Tex - RP | 819 | 1.1 | 0 | 0 | 2 | 33.75 | 6.00 | |
| Tommy Kahnle | CWS - RP | 836 | 33.1 | 0 | 2 | 39 | 4.86 | 1.77 | |
| Scott Carroll | CWS - RP | 611 | 36.2 | 1 | 0 | 27 | 3.44 | 1.45 | |
| Chris Martín | NYY - RP | 807 | 20.2 | 0 | 1 | 18 | 5.66 | 1.65 | |
| Matt Barnes | Bos - RP | 833 | 43.0 | 3 | 0 | 39 | 5.44 | 1.65 | |
| Dan Otero | Cle - RP | 932 | 46.2 | 2 | 0 | 28 | 6.75 | 1.50 | |
| Enny Romero | TB - RP | 854 | 30.0 | 0 | 0 | 31 | 5.10 | 1.73 | |
| T.J. McFarland | Bal - RP | 869 | 40.1 | 2 | 0 | 26 | 4.91 | 1.74 | |
| Tanner Scheppers | Tex - RP | 733 | 38.1 | 4 | 0 | 32 | 5.63 | 1.57 | |
| Mayckol Guaipe | Sea - RP | 868 | 26.2 | 0 | 0 | 22 | 5.40 | 1.76 | |
| Roberto Hernández | Tor - SP,RP | 784 | 84.2 | 3 | 0 | 42 | 4.36 | 1.37 | |
| Bobby Parnell | Det - RP | 873 | 24.0 | 2 | 1 | 13 | 6.38 | 1.96 | |
| J.R. Graham | Min - RP | 876 | 63.2 | 1 | 0 | 53 | 4.95 | 1.48 | |
| Rob Rasmussen | LAA - RP | 893 | 15.1 | 2 | 0 | 17 | 9.98 | 2.22 | |
| Bryan Mitchell | NYY - RP | 907 | 29.2 | 0 | 1 | 29 | 6.37 | 1.79 | |
| Cam Bedrosian | LAA - RP | 865 | 33.1 | 1 | 0 | 34 | 5.40 | 1.77 | |
| Cody Martin | Sea - RP | 912 | 30.2 | 2 | 0 | 27 | 7.92 | 1.70 | |
| Jake Brigham | Det - RP | 927 | 16.2 | 0 | 0 | 12 | 8.64 | 2.16 | |
| David Rollins | Sea - RP | 928 | 25.0 | 0 | 0 | 21 | 7.56 | 1.80 | |
| R.J. Álvarez | Oak - RP | 952 | 20.0 | 0 | 0 | 23 | 9.90 | 2.00 | |
| Daniel Webb | CWS - RP | 949 | 30.0 | 1 | 0 | 22 | 6.30 | 2.10 | |
| Ryan Cook | Sea - RP | 973 | 8.2 | 0 | 0 | 6 | 18.69 | 3.12 | |
| Justin De Fratus | Sea - RP | 989 | 80.0 | 0 | 0 | 68 | 5.51 | 1.55 | |
| Héctor Noesí | CWS - SP,RP | 954 | 32.2 | 0 | 0 | 22 | 6.89 | 1.78 | |
| Odrisamer Despaigne | Bal - SP,RP | 1006 | 125.2 | 5 | 0 | 69 | 5.80 | 1.38 | |
| Buck Farmer | Det - SP,RP | 1001 | 40.1 | 0 | 0 | 24 | 7.36 | 1.74 | |
| Jeremy Guthrie | Tex - SP,RP | 1101 | 148.1 | 8 | 0 | 84 | 5.95 | 1.55 | |